学术论文
自2015年以来，实验室累计发表重要学术论文72篇。代表性学术论文如下：
| 序号 | 论文题目 | 刊物名称 | 年，卷（期）：起止页码 |
| 1 | Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors. | Bioorganic & medicinal chemistry | 2015 Oct 1;23(19):6250-7 |
| 2 | Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors. | Eur J Med Chem | 2016 Mar 3;110:115-25 |
| 3 | Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors. | Bioorg Med Chem | 2016 Mar 1;24(5):1079-88 |
| 4 | Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin β-subunit in Pichia pastoris. | Biotechnol Lett. | 2016 May;38(5):801-7 |
| 5 | Stability-indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-TOF/MS, LC-MS/MS and NMR. | J Pharm Biomed Anal | 2016 Mar 16;125:165-177 |
| 6 | Protection of Neuronal Cells from Excitotoxicity by Disrupting nNOS-PSD95 Interaction with a Small Molecule SCR-4026 | Brain Res | 2016 Jul 12. pii: S0006-8993(16)30486-3. |
| 7 | Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability | AAPS PharmSciTech | 2016 Jun;17(3):757-66. |
| 8 | Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer | Journal of experimental & clinical cancer research | 2017 Volume: 36, Issue: 1, Pages: 160 |
| 9 | A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8(+) T cell responses and antitumor effect |
Vaccine | 2017 Volume: 35, Issue: 47, Pages: 6459-6467 |
| 10 | Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation | Genome research | 2017 Volume: 27, Issue: 10, Pages: 1715-1729 |
| 11 | The retention of prion protein in the endoplasmic reticulum prevents N2A cells from proteasome inhibitioninduced cytotoxicity | Biochemical and biophysical research communications | 2017 Volume: 491, Issue: 2, Pages: 500-507 |
| 12 | A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study |
Journal of chromatographic science | 2017 Volume: 55, Issue: 6, Pages: 595-602 |
| 13 | Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors | Bioorganic & medicinal chemistry | 2017 Volume: 25, Issue: 1, Pages: 75-83 |
| 14 | Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors | Bioorganic & medicinal chemistry | 2018 Volume；26，Issue：18, Pages；5029-5036 |
| 15 | Effective sustained release of 5-FU-loaded PLGA implant for improving therapeutic index of 5-FU in colon tumor | International journal of pharmaceutics | 2018 Volume；550，Issue：1-2；Pages；380-387 |
| 16 | Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents | Bioorganic & medicinal chemistry letters | 2018 Volume：28，Issue：10，Pages：1731-1735 |
| 17 | Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy | Bioorganic & medicinal chemistry letters | 2018 Volume：28，Issue：17，Pages：3004-3008 |
| 18 | Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing | AMA oncology | 2018 |
| 19 | Detection of pathogens from resected heart valves of patients with infective endocarditis by next-generation sequencing | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Journal; Article; (JOURNAL ARTICLE) |
2019 E-ISSN:1878-3511 |
| 20 | Discovery of potent anti-inflammatory 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl) pyrimidin-2-amines for use as Janus kinase inhibitors | Bioorganic & medicinal chemistry | 2019 E-ISSN:1464-3391 |
| 21 | 2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development | European journal of medicinal chemistry | 2019 E-ISSN:1768-3254 |
