学术论文

自2015年以来,实验室累计发表重要学术论文72篇。代表性学术论文如下:

序号 论文题目 刊物名称 年,卷(期):起止页码
1 Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors. Bioorganic & medicinal chemistry 2015 Oct 1;23(19):6250-7
2 Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors. Eur J Med Chem 2016 Mar 3;110:115-25
3 Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors. Bioorg Med Chem 2016 Mar 1;24(5):1079-88
4 Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin β-subunit in Pichia pastoris. Biotechnol Lett. 2016 May;38(5):801-7
5 Stability-indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-TOF/MS, LC-MS/MS and NMR. J Pharm Biomed Anal 2016 Mar 16;125:165-177
6 Protection of Neuronal Cells from Excitotoxicity by Disrupting nNOS-PSD95 Interaction with a Small Molecule SCR-4026 Brain Res 2016 Jul 12. pii: S0006-8993(16)30486-3.
7 Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability AAPS PharmSciTech 2016 Jun;17(3):757-66.
8 Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer Journal of experimental & clinical cancer research 2017 Volume: 36, Issue: 1, Pages: 160
9 A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein
and Fms-like tyrosine kinase-3 ligand induces CD8(+) T cell responses and antitumor effect
Vaccine 2017 Volume: 35, Issue: 47, Pages: 6459-6467
10 Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation Genome research 2017 Volume: 27, Issue: 10, Pages: 1715-1729
11 The retention of prion protein in the endoplasmic reticulum prevents N2A cells from proteasome inhibitioninduced cytotoxicity Biochemical and biophysical research communications 2017 Volume: 491, Issue: 2, Pages: 500-507
12 A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical
Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study
Journal of chromatographic science 2017 Volume: 55, Issue: 6, Pages: 595-602
13 Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors Bioorganic & medicinal chemistry 2017 Volume: 25, Issue: 1, Pages: 75-83
14 Novel 4-​(2-​pyrimidinylamino)​benzamide derivatives as potent hedgehog signaling pathway inhibitors Bioorganic & medicinal chemistry 2018 Volume;26,Issue:18, Pages;5029-5036
15 Effective sustained release of 5-​FU-​loaded PLGA implant for improving therapeutic index of 5-​FU in colon tumor International journal of pharmaceutics 2018 Volume;550,Issue:1-2;Pages;380-387
16 Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents Bioorganic & medicinal chemistry letters 2018 Volume:28,Issue:10,Pages:1731-1735
17 Design, synthesis and evaluation of novel N-​phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy Bioorganic & medicinal chemistry letters 2018 Volume:28,Issue:17,Pages:3004-3008
18 Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-​Scale Sequencing AMA oncology 2018
19 Detection of pathogens from resected heart valves of patients with infective endocarditis by next-​generation sequencing International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Journal; Article; (JOURNAL ARTICLE)
2019
E-ISSN:1878-3511
20 Discovery of potent anti-​inflammatory 4-​(4,​5,​6,​7-​tetrahydrofuro[3,​2-​c]​pyridin-​2-​yl) pyrimidin-​2-​amines for use as Janus kinase inhibitors Bioorganic & medicinal chemistry 2019
E-ISSN:1464-3391
21 2,​7-​naphthyridinone-​based MET kinase inhibitors: A promising novel scaffold for antitumor drug development European journal of medicinal chemistry 2019
E-ISSN:1768-3254